|
KMID : 0379520000160030187
|
|
한국독성학회지
2000 Volume.16 No. 3 p.187 ~ p.193
|
|
|
Prophylactic Detoxification by Physostigmine and Procyclidine of Diisopropylfluorophosphate Poisoning
|
|
Kim Yun-Bae
Hur Gyeung-Haeng
Shin Sung-Ho
Yeon Gyu-Baek
Kang Jong-Koo
Park Seung-Ju
|
|
|
Abstract
|
|
|
|
The antidotal, anticonvulsant and neuroprotective effects of physostigmine and procyclidine. the combinational prophylactics for organophosphate poisoning, were evaluated in rats. In comparison with a low protective effect (1.6 fold) of atropine (15 mg/kg) and 2-pralidoxime (30 mg/kg), the traditional antidotes regimen, a marked protection ratio of 7.3 fold was achieved by combinational pretreatment with physostigmine (0.05 mg/kg) and procyclidine (10 mg/kg), which was superior to that (3.5 fold) with pyri-dostigmine (0.1 mg/kg) and atropine (15 mg/kg). Rats exposed to a high dose (10 mg/kg. 2 X LD_{50}) of diisopropylfluorophosphate showed severe epileptiform seizures on electroencephalography, resulting in necrotic and apoptotic brain injuries in discrete brain regions under histopathological and TUNEL immuno-histochemical examinations in 24 hr. Such seizures and excitotoxic brain injuries were fully prevented by pretreatment with physostigmine (0.05 mg/kg) and procyclidine (10 mg/kg). in contrast to a negligible effect of pyridostigmine (0.1 mg/kg) and atropine (15 mg/kg). Taken together, it is proposed that the prophylactics composed of physostigmine and procyclidine could be a promising regimen for the prevention of lethality, seizures and brain injuries induced by organophosphate poisoning.
|
|
|
KEYWORD
|
|
|
Physostigmine, Procyclidine, Organophosphate, Seizures, Brain injuries, Neuroprotection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|